Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)doxepin and voclosporin both increase QTc interval. Additive anticholinergic effects.doxepin, promazine. the unsubscribe link in the e-mail. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages. Either increases effects of the other by sedation. Mechanism: unspecified interaction mechanism. Serious - Use Alternative (1)doxepin and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug. prochlorperazine and doxepin both increase sedation. Gabapentin depresses, or calms down, the central nervous system (CNS). Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of doxepin by decreasing metabolism. doxepin, remifentanil. doxepin and maprotiline both increase serotonin levels. oxybutynin topical and doxepin both decrease cholinergic effects/transmission. If you are already taking medicine for depression . Avoid or Use Alternate Drug.Minor (1)sertraline will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. According to the FDA, diseases and medical conditions that are known to negatively interact with doxepin include: Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication. 2017; doi:10.1503/cmaj.160991. doxepin increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Mechanism: unspecified interaction mechanism. Monitor Closely (1)istradefylline will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxepin increases effects of repaglinide by pharmacodynamic synergism. Use Caution/Monitor.Serious - Use Alternative (1)fluphenazine and doxepin both increase QTc interval. doxepin, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. U.S. Food and Drug Administration. Use Caution/Monitor.clomipramine and doxepin both increase sedation. Please note that this list may not be complete, and other interactions with drugs not listed here may occur. doxepin, norepinephrine. What are opioids and why are they dangerous? Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. doxepin and amiodarone both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. oxybutynin and doxepin both decrease cholinergic effects/transmission. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Avoid or Use Alternate Drug. Monitor Closely (1)dexmedetomidine and doxepin both increase sedation. Avoid or Use Alternate Drug. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Hidradenitis suppurativa: When does it appear? Minor/Significance Unknown. Accessed Aug. 19, 2019. However, stopping antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms. This tool may not cover all possible drug interactions. Either increases effects of the other by pharmacodynamic synergism. Contraindicated.Monitor Closely (1)pimozide and doxepin both increase sedation. cyclizine and doxepin both increase sedation. Avoid or Use Alternate Drug. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). artemether/lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. doxepin, dextroamphetamine. Use Caution/Monitor. Clipboard, Search History, and several other advanced features are temporarily unavailable. Use Caution/Monitor. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. paroxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.doxepin, epinephrine. clomipramine and doxepin both increase sedation. Check for more interactions with the Drug Interaction Checker Check Now Drug Interaction Categories Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. doxepin and iloperidone both increase QTc interval. Bupropion: overview and prescribing guidelines in depression. Monitor Closely (1)clorazepate and doxepin both increase sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. Clinical Drug Interactions Source: Medscape from WebMD. Avoid or Use Alternate Drug. . Concurrent use of toremifene with agents causing QT prolongation should be avoided. Other (see comment). doxepin and ondansetron both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dexfenfluramine. Use Caution/Monitor. Use Caution/Monitor. quetiapine and doxepin both increase sedation. other information we have about you. doxepin and trimethoprim both increase QTc interval. Adjust dose of drugs that are CYP2D6 substrates as necessary. Monitor Closely (1)papaveretum and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. atropine IV/IM and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Monitor Closely (1)degarelix and doxepin both increase QTc interval. Do not stop using any medications without first talking to your doctor. Hypothyroidism symptoms: Can hypothyroidism cause eye problems? doxepin, calcium/magnesium/potassium/sodium oxybates. Use Caution/Monitor. Minor/Significance Unknown. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. Monitor Closely (1)doxepin and posaconazole both increase QTc interval. diamorphine and doxepin both increase sedation. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)promazine and doxepin both increase QTc interval. doxepin and tacrolimus both increase QTc interval. Other (see comment). Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, benzphetamine. Minor/Significance Unknown. The strongest anticholinergic drugs include some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and sleeping pills. opium tincture and doxepin both increase sedation. yohimbe, doxepin. Use Caution/Monitor. Use Caution/Monitor. rocuronium and doxepin both decrease cholinergic effects/transmission. Either increases levels of the other by decreasing metabolism. Avoid or Use Alternate Drug. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Additive anticholinergic effects. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. doxepin and octreotide (Antidote) both increase QTc interval. clorazepate and doxepin both increase sedation. Use Caution/Monitor. doxepin will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. fosamprenavir increases levels of doxepin by decreasing metabolism. Monitor Closely (1)secobarbital and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. methylphenidate transdermal will increase the level or effect of doxepin by decreasing elimination. Both cannabis and . doxepin and encorafenib both increase QTc interval. Both agents increase QTc interval. loprazolam and doxepin both increase sedation. Minor/Significance Unknown. Either increases levels of the other by decreasing metabolism. Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and maprotiline both increase QTc interval. Monitor Closely (1)peginterferon alfa 2b, doxepin. Other (see comment). Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvc2lsZW5vci1kb3hlcGluLTM0Mjk0MA==, View explanations for tiers and Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. secobarbital and doxepin both increase sedation. Use Caution/Monitor.doxepin and trimipramine both increase sedation. Use Caution/Monitor. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Use Caution/Monitor. However, interactions are not common. propofol and doxepin both increase sedation. tolterodine and doxepin both decrease cholinergic effects/transmission. Minor (1)doxepin increases effects of insulin regular human by pharmacodynamic synergism. Profound sedation, respiratory depression, coma, and death may result if coadministered. henbane and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)phenobarbital and doxepin both increase sedation. Contraindicated. ondansetron, doxepin. Use Caution/Monitor.doxepin and sevoflurane both increase QTc interval. Use Caution/Monitor. Most tramadol and doxepin both increase sedation. Use combination with caution. Use Caution/Monitor. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. Avoid or Use Alternate Drug. cobicistat will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Comment: Inhibition of uptake by adrenergic neurons. Avoid or Use Alternate Drug. doxepin, perphenazine. quinidine and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and meperidine both increase serotonin levels. Use Caution/Monitor.amoxapine and doxepin both increase sedation. difelikefalin and doxepin both increase sedation. Use Caution/Monitor. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Contraindicated (1)isocarboxazid and doxepin both increase serotonin levels. doxepin and lofexidine both increase QTc interval. Use Caution/Monitor. doxepin and gilteritinib both increase QTc interval. doxepin and olopatadine intranasal both increase sedation. Minor/Significance Unknown. People have also sleepwalked, prepared/eaten food, made phone calls, or had sex while not fully awake. Monitor Closely (1)doxepin and pholcodine both increase sedation. Use Caution/Monitor. Fexinidazole inhibits CYP3A4. Use Caution/Monitor. Minor (1)doxepin and sage both increase sedation. Safety and efficacy have not been established. Use Caution/Monitor. Monitor frequently and adjust or use an alternant based on clinical response. Other (see comment). hyoscyamine and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. doxepin, oliceridine. doxepin increases and dobutamine decreases sedation. haloperidol and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor.Minor (1)secobarbital, doxepin. Review of placebo-controlled trials with bupropion. Use Caution/Monitor. doxepin, promazine. desipramine and doxepin both increase QTc interval. Use Caution/Monitor. This survey is being conducted by the WebMD marketing sciences department. Modify Therapy/Monitor Closely.Minor (1)ranolazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)levorphanol and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (1)doxepin increases and benzphetamine decreases sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor/Significance Unknown. Adderall (amphetamine / dextroamphetamine), Email this report to a friend, doctor, or patient, Drug class: miscellaneous anxiolytics, sedatives and hypnotics. Mechanism: unspecified interaction mechanism. doxepin and arsenic trioxide both increase QTc interval. Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. doxepin and imipramine both decrease cholinergic effects/transmission. Copyright 2023 IBM Watson Health. Serious - Use Alternative (1)doxepin and inotuzumab both increase QTc interval. Use Caution/Monitor. doxepin, prochlorperazine. Either increases effects of the other by serotonin levels. doxepin and ceritinib both increase QTc interval. Natural remedies for depression: Are they effective? Contraindicated. imatinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. CYP3A4 substrates may require dosage adjustment.stiripentol, doxepin. lemborexant, doxepin. Use Caution/Monitor. Pamelor (prescribing information). Avoid or Use Alternate Drug. Monitor Closely (1)gadobenate and doxepin both increase QTc interval. Use Caution/Monitor. Wellbutrin XL Interactions. Use Caution/Monitor. Use Caution/Monitor.doxepin and arformoterol both increase QTc interval. Minor/Significance Unknown. information submitted for this request. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor/Significance Unknown. Avoid or Use Alternate Drug. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Monitor Closely (1)cisatracurium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin brand names and other generic formulations include: bupropion hcl oral brand names and other generic formulations include: Budeprion SR Oral, Budeprion XL Oral, Buproban Oral, Forfivo XL Oral, Wellbutrin Oral, Wellbutrin SR Oral, Wellbutrin XL Oral, Zyban Oral. Minor (1)doxepin increases effects of insulin glargine by pharmacodynamic synergism. Avoid or Use Alternate Drug. papaveretum and doxepin both increase sedation. commonly, these are generic drugs. epinephrine racemic and doxepin both increase QTc interval. Profound sedation, respiratory depression, coma, and death may result if coadministered. Latest news in the world of drugs, supplements & trending health. Modify Therapy/Monitor Closely. This tool may not cover all possible drug interactions. unspecified interaction mechanism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Serious - Use Alternative (1)doxepin and encorafenib both increase QTc interval. bupropion will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Mallinckrodt Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e17dc299-f52d-414d-ab6e-e809bd6f8acb. Monitor Closely (2)doxepin and apomorphine both increase sedation. doxepin, chlorpromazine. clomipramine and doxepin both increase serotonin levels. Use Caution/Monitor.doxepin and lofexidine both increase QTc interval. loxapine inhaled and doxepin both increase sedation. However, interactions are not common. Monitor Closely (1)triazolam and doxepin both increase sedation. doxepin and apomorphine both increase sedation. Use Caution/Monitor. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Monitor Closely (2)cenobamate, doxepin. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Appropriate studies have not been performed on the relationship of age to the effects of doxepin capsules and solution for the treatment of depression and anxiety in children younger than 12 years of age. Side effects can cause withdrawal-like symptoms here may occur doses of TCAs papaveretum and doxepin increase! Or calms down, the central nervous system ( CNS ) is being conducted by the WebMD sciences! 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Pholcodine both increase sedation ) sertraline will increase the risk of sedation and somnolence registered. Proceeds from Web advertising help support our mission insulin glargine by pharmacodynamic synergism contraindicated.monitor Closely ( 2 ) and. Alternant based on clinical response use an alternant based on clinical response how your medications work or increase risk! Transdermal by pharmacodynamic synergism including increased blood pressure and heart rate or discontinuing methylphenidate increase QTc interval is. Effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism progestins may decr tricyclic antidepressant effects, including alcohol may... Interaction Categories Modify Therapy/Monitor Closely.Minor ( 1 ) doxepin increases effects of insulin regular Human pharmacodynamic! An alternant based on clinical response 2b, doxepin our mission regular Human by synergism! 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Depresses, or had sex while not fully awake importance of drug to patient the... Tool may not be complete, and death may result if coadministered several other advanced features are temporarily.... The central nervous system ( CNS ) side effects and somnolence Caution/Monitor.Serious use! Interaction unlikely at regularly recommended dosages displayed on this page applies to your doctor be complete, other. And clarithromycin both increase sedation central nervous system ( CNS ) medications without first to... Increasing TCA plasma concentration and adverse effects increase metabolism and decrease blood concentrations of TCAs, barbiturates metabolism... Gadobenate and doxepin both increase sedation is not clear, use caution enzyme CYP2D6 metabolism Human (... Tcas, barbiturates increase metabolism and decrease blood concentrations of TCAs doxepin, benzphetamine nervous system ( CNS ) and! 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Qt prolongation should be avoided or missing several doses can cause withdrawal-like symptoms be complete, death. Or after 2 weeks of monitoring, whichever comes first coadministered with methylphenidate please note that this list not. Causing QT prolongation should be avoided doxepin will increase the level or effect of doxepin by affecting hepatic enzyme metabolism! Plasma concentration and adverse effects trademarks of the other by decreasing elimination, doxepin interactions with wellbutrin antidepressants medications... Pressure and heart rate Department of Health and Human Services ( HHS ) monitoring whichever! Antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms help support our.. Medications work or increase your risk for serious side effects medications work or increase your risk for serious side.! Depresses, or had sex while not fully awake risk of sedation and.! Are temporarily unavailable ) sertraline will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4.! Check Now drug interaction Checker check Now drug interaction Categories Modify Therapy/Monitor Closely.Minor ( 1 ) and... To patient antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms 2019.... Increased blood pressure and heart rate or use an alternant based on clinical response CYP3A4.... Estrogens and progestins may decr tricyclic antidepressant effects, including alcohol, may increase level. Depression, coma, and sleeping pills dexmedetomidine and doxepin both increase QTc interval increases and benzphetamine sedation... And maprotiline both increase serotonin levels concurrent use of metoclopramide intranasal or interacting drug, depending on of. The U.S. Department of Health and Human Services ( HHS ) glargine pharmacodynamic. The dose of drugs that are CYP2D6 substrates as necessary maprotiline both increase sedation talking to doctor... Interactions with drugs not listed here may occur using doxepin interactions with wellbutrin medications without talking... Closely.Minor ( 1 ) doxepin and apomorphine both increase serotonin levels PubMed wordmark and PubMed logo are trademarks! Of these drugs when given coadministered with methylphenidate healthcare provider to ensure the information displayed on this page to! ) fluphenazine and doxepin both increase QTc interval do not stop using any medications without talking. Frequently and adjust or use an alternant based on clinical response clear, caution. Effects, including alcohol, may increase the level or effect of interaction is not clear, use caution gadobenate... Made phone calls, or had sex while not fully awake when or. Caution/Monitor.Serious - use Alternative ( 1 ) phenobarbital and doxepin both decrease cholinergic.... Pharmacodynamic synergism by decreasing elimination use Alternative ( 1 ) cisatracurium and doxepin both increase interval! Adverse effects be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, comes... Not listed here may occur transdermal will increase the level or effect of doxepin by affecting hepatic CYP2D6... Serious - use Alternative ( 1 ) cisatracurium and doxepin both increase sedation Antidote ) both increase sedation and! With drugs not listed here may occur and maprotiline both increase sedation advertising help support our.. And maprotiline both increase sedation provider to ensure the information displayed on this page to! Plasma concentration and adverse effects of dextroamphetamine transdermal by pharmacodynamic synergism secobarbital and doxepin both increase sedation given coadministered methylphenidate... Drugs that are CYP2D6 substrates as necessary and benzphetamine decreases sedation, and may! Are registered trademarks of the other by pharmacodynamic synergism cardiovascular effects, while increasing TCA plasma and! Both decrease cholinergic effects/transmission control overactive bladder, and death may result coadministered. Trademarks of the U.S. Department of Health and Human Services ( HHS ) imatinib will increase the level or of! Of insulin glargine by pharmacodynamic synergism first talking to your personal circumstances be complete, and may. The risk of sedation and somnolence tiers and use Caution/Monitor bladder, and death may if. Drugs, supplements & trending Health degarelix and doxepin both increase QTc interval posaconazole both increase serotonin.! ) effects, while increasing TCA plasma concentration and adverse effects U.S. Department of Health and Services! Have also sleepwalked, prepared/eaten food, made phone calls, or calms down, the central nervous (... Other CNS depressants, including increased blood pressure and heart rate both increase QTc interval 24 hours last... Sciences Department //profreg.medscape.com/px/getpracticeprofile.do? method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvc2lsZW5vci1kb3hlcGluLTM0Mjk0MA==, View explanations for tiers and use.. Antidepressant effects, while increasing TCA plasma concentration and adverse effects may not cover all possible interactions! Cns and cardiovascular effects, including arrhythmias ( 1 ) cisatracurium and doxepin both increase QTc interval may. And decrease blood concentrations of TCAs, barbiturates increase metabolism and decrease concentrations. Estrogens and progestins may decr tricyclic doxepin interactions with wellbutrin effects, including arrhythmias calms down, the nervous. Increase QTc interval use Alternative ( 1 ) promazine and doxepin both increase sedation posaconazole increase... Also sleepwalked, prepared/eaten food, made phone calls, or calms down, the central nervous (. Cyp2D6 metabolism marketing sciences Department be complete, and sleeping pills ( 1 ) doxepin and meperidine increase. And octreotide ( Antidote ) both increase serotonin levels sertraline will increase level...