Eur. Med. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models. Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. Nat. Leuk Lymphoma. Scatter correction, randoms correction, and dead time correction were also performed. Isik, E.G. Vol. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma, Patients should follow up with an oncologist every three to six months for the first two years. We extracted all 18 first-order features (energy, total energy, entropy, kurtosis, maximum, minimum, mean, median, interquartile range (IQR), skewness, range, mean absolute deviation (MAD), robust mean absolute deviation (RMAD), root mean squared (RMS), variance, uniformity, 10th percentile and 90th percentile); furthermore, 14 shape features as well as all second- and higher-order features (24Gy level co-occurrence matrix (GLCM) features, 14Gy level dependence matrix (GLDM) features, 16Gy level run-length matrix (GLRLM) features, 16Gy level size zone matrix (GLSZM) features, and five neighboring gray tone difference matrix (NGTDM) features25). HL is often curable by conventional chemotherapy and radiotherapy. This content is owned by the AAFP. Disclaimer. Kursa, M. B. Praznik: High performance information-based feature selection. Cancer 2005;104:1066-74. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. Robin, X. et al. 2016 Sep;95(9):1521-35. doi: 10.1007/s00277-016-2736-5. The most common subtype, diffuse large B-cell lymphoma, has a 40% lifetime relapse rate.37 Lifetime relapse in Hodgkin lymphoma occurs in 10% to 15% of patients with early stage disease and 40% of patients with advanced stage disease.38, Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force.39 Complications of lymphoma treatment include secondary malignancies (e.g., breast, lung, skin, colon), cardiac disease, infertility, and endocrine, neurologic, and psychiatric dysfunctions. Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. and transmitted securely. Early chemotherapy intensification with escalated BEACOPP in patients with advanced-stage Hodgkin 10 Results showed superior results for patients who were PET negative. For this, we considered the readings from S.N.N. The evaluation was carried out independently by two readers [Reader 1: S.N.N., Reader 2: L.J.J.] ; writingreview and editing, S.N.N., J.M.M.R., D.K., B.H., I.G.S. Score 3 should be interpreted according to the clinical context but in many Hodgkins Lymphoma patients indicates a good prognosis with standard treatment. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc. Patients with a Deauville score of 1 to 2 were considered PET negative and randomized to either 30 Gy IFRT or no further treatment, and patients with a Deauville score of 3 to 5 underwent a fourth cycle of ABVD and IFRT. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. The relevant cutoff was between DS3 and DS4 and defined by a qPET value of 1.323: lesions equal or above were classified as DS4-positive, lesions below as DS4-negative. ; project administration, S.P. Patient information: See related handout on lymphoma, written by the authors of this article. Would you like email updates of new search results? Any tobacco use and obesity are major modifiable risk factors, with genetic, infectious, and inflammatory etiologies also contributing. Radiotherapy can also lead to long-term complications, including cardiac and pulmonary toxicity, hypothyroidism, or breast or lung cancers.2432 Radiotherapy can be avoided in patients with stage IA or IIA lymphoma without bulky disease25 (Table 319). ; project administration, S.N.N. EJNMMI Phys. Household contacts should receive appropriate CDC-recommended immunizations.43, This article updates a previous article on this topic by Glass.46. PET/CT, however, is not always available or may be missing for one or more time points, precluding a reliable prognostic statement based on metabolic activity. https://doi.org/10.1148/radiol.2018172361 (2018). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). All further statistical analyses were then performed scanner-wise: differences between DS4+ and DS4 manifestations were assessed with the MannWhitney-U-test and single feature performances with the ROC-analysis. https://doi.org/10.1158/0008-5472.CAN-17-0339 (2017). Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). 2016 Apr;95(5):695-706. doi: 10.1007/s00277-016-2619-9. Mol. An official website of the United States government. PET/CT scanning and reconstruction details are summarized in Table 3. 58, 282287. J. Nucl. Pretransplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). R package version 6.093. https://doi.org/10.1080/10428194.2020.1786555 (2020). 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. ; Weller, E.; Backstrand, K.H. ; investigation, S.P. No special Save my name, email, and website in this browser for the next time I comment. Mayerhoefer, M. E., Umutlu, L. & Schoder, H. Functional imaging using radiomic features in assessment of lymphoma. deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * ; Kluge, R. FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas. Cheson, B. D. et al. Prognostic value of pretransplant FDG-PET in refractory/relapsed Hodgkin lymphoma treated with autologous stem cell transplantation: systematic review and meta-analysis. https://doi.org/10.5152/dir.2015.15220 (2016). Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. Cancer Res. 6, 8. https://doi.org/10.1186/s40658-019-0244-0 (2019). J. Pers. WebTreatment was not modified based on imaging, and 90% patients achieved a negative iPET (Deauville score 1-3) after two cycles. Web- The Deauville score for interpreting FDG-PET in lymphoma - Lugano classification for staging of lymphomas - Unfavorable prognostic factors early HL - IPS Hodgkin lymphoma; Figures - Lymph node regions lymphoma; CALCULATORS. Exp Hematol Oncol. Explorative analysis and modeling of these data aim to correlate features with prediction targets, such as survival or malignancy11. Cancers (Basel) 13. https://doi.org/10.3390/cancers13143634 (2021). The results of the present study show that the first-order feature median has a high sensitivity for DS4+ manifestations on two different scanners (scanner A: 0.91, scanner B: 0.85). Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. Performing texture analysis with a non-contrast-enhanced CT is also less expensive and time-consuming than PET/CT. Med. https://doi.org/10.1016/j.ymeth.2020.06.020 (2021). Flechsig, P. et al. R package version 4.71. Sau Yip Hui et al., Case Rep, 2022. and L.J.J.. We applied different methods to reduce the number of features in both datasets separately by dropping features with a correlation of more than 95% using the Hmisc package for R33 (Version 4.7.1), applying the minimum redundancy maximum relevance method from the praznik package for R34 (Version 11.0.0) selecting 20 (mrmr20) and 10 (mrmr10) features and with the recursive feature elimination (rfe) from the caret package for R35 (Version 6.0.93). Particularly, there was a significant difference in PFS between patients with interim score 12 and those with score 3. Fifty-one examinations were conducted on scanner A and 24 examinations on scanner B (scanning details in the next section). The readers were required to delineate as much of the target lesion as possible while keeping a minimum distance of 12 pixels from the edge. Furth, C.; Steffen, I.G. WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. WebA Biblioteca Virtual em Sade uma colecao de fontes de informacao cientfica e tcnica em sade organizada e armazenada em formato eletrnico nos pases da Regio Latino-Americana e do Caribe, acessveis de forma universal na Internet de modo compatvel com as bases internacionais. All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. The .gov means its official. doi: 10.1016/S2352-3026(21)00102-2. On scanner B, only flatness and median were selected by all methods. 2012;30(18):2183-2189. https://doi.org/10.1007/s11307-017-1155-x (2018). 2002;359(9323):2065-2071. WebDeauville scores improve the clinical utility of end-of-chemotherapy PET, as evidenced by an increase in positive predictive value to 72.7% from 44.4% on the basis of report alone. Moskowitz AJ, Schder H, Gavane S, Thoren KL, Fleisher M, Yahalom J, McCall SJ, Cadzin BR, Fox SY, Gerecitano J, Grewal R, Hamlin PA, Horwitz SM, Kumar A, Matasar M, Ni A, Noy A, Palomba ML, Perales MA, Portlock CS, Sauter C, Straus D, Younes A, Zelenetz AD, Moskowitz CH. ; Sherbiny, H.S. 2023 Standard of Care. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. The statistical analysis involved several steps. 2023, 13, 445. WebINTRODUCTION. Article Of these, 95.2% of scans scored DS 13 were kept on following or the same treatment plan was continued and patients did well. The image biomarker standardization initiative: Standardized quantitative radiomics for high-throughput image-based phenotyping. ; Schwartz, L.H. We included a total of 75 PET/CT datasets acquired in 43 patients. https://doi.org/10.1053/j.semnuclmed.2017.09.007 (2018). Considering the dataset of scanner B, this accounted for 26 features. the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, Rep. 9, 1322. https://doi.org/10.1038/s41598-018-37197-z (2019). The Infona portal uses cookies, i.e. 2016;17(9):1283-1294. Required fields are marked *. The author has an hindex of 2, co-authored 11 publication(s) receiving 8 citation(s). Furth, C.; Steffen, I.G. ; visualization, S.N.N., L.J.J. WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. 2021;62(8):1102-1111. doi: 10.11406/rinketsu.62.1102. 2017 May 25;5(5):CD007941. Comparison of commonly used SUV metrics for differentiation between paediatric tumours. On this Wikipedia the language links are at the top of the page across from the article title. Yhim HY, Eshet Y, Metser U, Lim CH, Lajkosz K, Isaev K, Cooper M, Prica A, Kukreti V, Bhella S, Lang N, Lee KH, Xu W, Hodgson D, Tsang R, Yoon SE, Kim SJ, Kim WS, Crump M, Kuruvilla J, Kridel R. Blood Adv. was considered. Our study has some limitations. Clipboard, Search History, and several other advanced features are temporarily unavailable. Hodgkin lymphoma (HL) is one of the most common cancer types in young adults with the incidence peaking in people in their 20s. 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